​昆 俊亮 研究室

○原著論文​

Nakai, K.,  Lin, H., Yamano, S., Tanaka, S., Kitamoto, S., Saitoh, H., Sakuma, K., Kurauchi, J., Akter, E., Konno, M., Ishibashi, K., Kamata, R., Ohashi, A., Koseki, J., Takahashi, H., Yokoyama, H., Shiraki, Y., Enomoto, A., Abe, S., Hayakawa, Y., Ushiku, T., Mutoh, M., Fujita, Y. and Kon, S♯. : Wnt activation disturbs cell competition  and causes diffuse invasion of transformed cells through NF-kB-MMP21 pathway.

Nature Communications, 14, 7048(Article number), 2023 ♯責任著者

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Akter, E., Tasaki, Y., Mori, Y., Nakai, K., Hachiya, K., Lin, H., Konno, M., Kamasaki, T., Tanabe, K., Umeda, Y., Yamano, S., Fujita, Y. and Kon, S♯. : Non-degradable autophagic vacuoles are indispensable for cell competition. 

Cell Reports, 40, 111292, 2022 ♯責任著者

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Igarashi, N., Miyata, K., Loo, T.M., Chiba, M., Hanyu, A., Nishio, M., Kawasaki, H., Zeng, H., Toyokuni, S., Kon, S., Moriyama, K., Fujita, Y. and Takahashi, A. : Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells.

Nature Communications, 13, s41467, 2022

 

Kajiwara, K., Chen, P., Abe,  Y., Okuda, S., Kon, S., Adachi, J., Tomonaga, T., Fujita, Y. and Okada, M. : Src activation in lipid raft confers epithelial cells with invasive potential to escape from apical extrusion during cell competition.

Current Biology,  32, 1-17, 2022

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Mori, Y., Shiratsuchi, N., Sato, N., Chaya, A., Tanimura, N., Ishikawa, S., Kato, M., Kameda, I., Kon, S., Haraoka, Y., Ishitani, T. and Fujita, Y. : Extracellular ATP facilitates cell extrusion from epithelial layers mediated by cell competition of apoptosis.

Current Biology, 32, 2144-2159, 2022

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Hata, M., Kinoshita, H., Hayakawa, Y., Konishi, M., Tsuboi, M., Oya, Y., Kurokawa, K., Hayata, Y., Nakagawa, H., Tateishi, H., Fujiwara, H., Hirata, Y., Worthley, DL., Muranishi, Y., Furukawa, T., Kon, S., Tomita, H., Wang, TC. and Koike, K. : GPR30-expressing gastric chief cells do not dedifferentiate but are eliminated via PDK-dependent cell competition during development of metaplasia.

Gastroenterology, 158, 1650-1666, 2020

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Watanabe, H., Ishibashi, K., Mano, H., Kitamoto, S., Sato, N., Hoshiba, K., Kato, M., Matsuzawa, F., Takeuchi, Y., Shirai, T., Ishikawa, S., Morioka, Y., Imagawa, T., Sakaguchi, K., Yonezawa, S., Kon, S♯. and Fujita, Y♯. : Mutant p53-expressing cells undergo necroptosis via cell competition with the neighboring normal epithelial cells.

Cell Reports, 23, 3721-3729, 2018 ♯同等責任著者

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Kon, S†., Ishibashi, K†., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T., Sasaki, Y., Enoki, R., Honma, S., Imamura, H., Oshima, M., Soga, T., Miyazaki, J., Duchen, M, R., Nam, J, M., Onodera, Y., Yoshioka, S., Kikuta, J., Ishii, M., Imajo, M., Nishida, E., Fujioka, Y., Ohba, Y., Sato, T. and Fujita, Y. : Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes.

Nature Cell Biology, 19, 530-541, 2017 †同等筆頭著者

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Saito, S., Maruyama, T., Yako, Y., Kajita, M., Fujioka, Y., Ohba, Y., Kasai, N., Sugama, N., Kon, S., Ishikawa, S., Hayashi, T., Yamazaki, T., Tada, M. and Fujita, Y. : Rab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells.

Proceedings of the National Academy of Sciences of the United States of America, 114, E2327-E2336, 2017

 

Yamamoto, S., Yako, Y., Fujioka, Y., Kajita, M., Kameyama, T., Kon, S., Ishikawa, S., Ohba, Y., Ohno, Y., Kihara, A. and Fujita, Y. : A role of the sphingosine-1-phosphate (S1P)- S1P receptor 2 pathway in Epithelial Defense Against Cancer (EDAC).

Molecular Biology of the Cell, 27, 491-499, 2016

 

Yamauchi, H., Matsumaru, T., Morita, T., Ishikawa, S., Maenaka, K., Takigawa, I., Semba, K., Kon, S. and Fujita, Y. : The cell competition-based high-throughput screening identifies small compounds that promote the elimination of RasV12-transformed cells from epithelia.

Scientific Reports, 5:15336, doi: 10.1038/srep15336, 2015

 

Ohoka, A., Kajita, M., Ikenouchi, J., Yako, Y., Kitamoto, S., Kon, S., Ikegawa, M., Shimada, T., Ishikawa, S. and Fujita, Y. : EPLIN is a crucial regulator for extrusion of RasV12-transformed cells. 

Journal of Cell Science, 128, 781-789, 2015

 

Kobayashi, N†., Kon, S†., Henmi, Y., Funaki, T., Satake, M. and Tanabe, K. : The Arf GTPase-activating protein SMAP1 promotes transferrin receptor endocytosis and interacts with SMAP2.

Biochemical and Biophysical Research Communications, 453, 473-479, 2014 †同等筆頭著者

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Wong, W, F., Looi, C, Y., Kon, S., Movahed, E., Funaki, T., Chang, L, Y., Satake, M. and Kohu, K. : T-cell receptor signaling induces proximal Runx1 transactivation via a calcineurin-NFAT pathway.

European Journal of Immunology, 44, 894-904, 2014

 

Funaki, T†., Kon, S†., Tanabe, K., Natsume, W., Sato, S., Shimizu, T., Yoshida, N., Wong, W, F., Ogura, A., Ogawa, T., Inoue, K., Ogonuki, N., Miki, H., Mochida, K., Endoh, K., Yomogida, K., Fukumoto, M., Horai, R., Iwakura, Y., Ito, C., Toshimori, K., Watanabe, T. and Satake, M. : An Arf GAP-encoding SMAP2 is necessary for the organized vesicles budding from the Trans-Golgi-network and subsequent acrosome formation in spermiogenesis.

Molecular Biology of the Cell, 24, 2633-2644, 2013 †同等筆頭著者

 

Kon, S., Minegishi, N., Tanabe, K., Watanabe, T., Funaki, T., Wong, W, F., Sakamoto, D., Higuchi, Y., Kiyonari, H., Asano, K., Iwakura, Y., Fukumoto, M., Osato, M., Sanada, S., Ogawa, S., Nakamura, T. and Satake, M. : SMAP1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia.

Journal of Clinical Investigation, 123, 1123-1137, 2013

 

Matsudaira, T., Uchida, Y., Tanabe, K., Kon, S., Watanabe, T., Taguchi, T. and Arai, H. : SMAP2 regulates retrograde transport from recycling endosomes to the Golgi.

PLoS ONE, e69145, 2013

 

Wong, W, F., Kohu, K., Nakamura, A., Ebina, M., Kikuchi, T., Tazawa, R., Tanaka, K., Kon, S., Funaki, T., Sugahara-Tobinai, A., Looi, C, Y., Endo, S., Funayama, R., Kurokawa, M., Habu, S., Ishi, N., Fukumoto, M., Nakata, K., Takai, T. and Satake, M. :  Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells.

Journal of Immunology, 188, 5408-5420, 2012

 

Suzuki, M., Tanaka, H., Tanimura, A., Tanabe, K., Oe, N., Rai, S., Kon, S., Fukumoto, M., Takei, K., Abe, T., Matsumura, I., Kanakura, Y. and Watanabe, T. : The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice.

PLoS ONE, e31854, 2012

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Funaki, T., Kon, S., Ronn, RE., Henmi, Y., Kobayashi, Y., Watanabe, T., Nakayama, K., Tanabe K. and Satake, M. : Localization of SMAP2 to the TGN and its function in the regulation of TGN protein transport.

Cell Structure and Function, 36, 83-95, 2011

 

Yamakoshi, H., Kanoh, N., Kudo, C., Sato, A., Ueda, K., Muroi, M., Kon, S., Satake, M., Ohmori, H., Ishioka, C., Oshima, Y., Osada, H., Chiba, N., Shibata, H. and Iwabuchi, Y. : KSRP/FUBP2 is a binding protein of G0-Y086, a cytotoxic curcumin analogue.

ACS Medicinal Chemistry Letters, 1, 273-276, 2010

 

Kofu, K., Ohmori, H., Wong, F, W., Onda, D., Wakoh, T., Kon, S., Yamashita, M., Nakayama, T., Kubo, M. and Satake, M. : The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3.

Journal of Immunology, 183, 7817-7824, 2009 

 

Kon, S., Tanabe, K., Watanabe, T., Sabe, H. and Satake, M. : Clathrin dependent endocytosis of E-cadherin is regulated by the Arf6GAP isoform SMAP1.

Experimental Cell Research, 314, 1415-1428, 2008

 

Natsume, W., Tanabe, K., Kon, S., Yoshida, N., Watanabe, T., Torii, T. and Satake, M. : SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network.

Molecular Biology of the Cell, 17, 2592-2603, 2006 

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